Mark,
I have been playing with the big bores for about 12 years now. Here is what I have found.
All of my rifles have had a slow rate of twist, 1:104, except for one with a Rayl barrel that had 1:99, IIFC. That didn't seem to make much difference.
On my current .62 with a 32" barrel, I target shoot with 135 grains of Ffg. Out to 50 yards, it pretty much clover leafs. I am sure someone with better eyes could maintain that further out. Not me, anymore.
I have run it up to 200 grains to shoot at distant silhouettes. They go clang, so it must be OK. I do fall short when shooting at the 400 yard clanger at the rifle range, however.
A while back, I did some chronograph testing with it, and using GOEX Cartridge grade powder, 200 grains gave me 1,994 fps. Pyrodex Select upped it to about 2004 fps.