Tin Type
The quick rule of thumb I use is that a rifle charge (in grains) should be the same as the size of the bore, and a maximum charge is twice that.
For a pistol, you halve those numbers.
So a fifty cal rifle would use a charge of fifty grains minimum, and a hundred max. A fifty cal pistol, start with twenty five grains and work up.
This is not a law carved in stone; just a handy rule to give you a starting point. It's enought charge to make sure the bullet leaves the barrel, but not enough to give you a nasty surprise, hopefully.
Technically, a pistol barrel should handle the same maximum load as a rifle without damage, but the recoil (as has been pointed out) can get REAL interesting! Remember, experience is what you get when you don't get what you expected! So increase those pistol loads SLOWLY.
Hope that helps
Dave