Hey Sean,
That 1860 is a sweet pistol. I really like the looks of it, the 1861 Navy and the 1862 Police. By this time, ol' Sam really had his act together and was producing mighty fine pistolas.
I would agree with the previous posts, that lighter loads will work better and more accurately than the heavier loads. I would start with 20 grains and work up from there. I would also think that using a filler between the powder and the ball to raise the placement of the ball in the chamber would be a good thing to do if you are shooting for accuracy and not just making smoke and noise.
I think Greyhunter has a good point about using a wad if possible and if not, greasing over the top of the ball. Like him, I do not think it has anything to do with preventing chain fires, but it will keep the fouling softer. I prefer the wad to the grease, as it is a lot less messy.
I always pinch the caps just a bit to make sure they stay placed on the nipples.
Enjoy. Let us know how it treats you.
John