It's what I have taught in ALL my classes for 30+ years,there is NO differance between a hunting load and a target load,actually there is ONE differance. It's where your feet are! If your feet are on the rifle range,that's your target load,if your out hunting,that's your hunting load!
Point is,use the most accurate load you can possably work up. We all have experianced what happens when you change your load + or - 5grs.
Here's an example using my,now Rick Evan's,.40cal. 42" Green Mt. coned muzzle. Just 5grs makes a world of differance. And this is a very forgiving barrel!
I dont have a lot of experiance with bullet's and fast twist,but I would imagine they would yeild simular result's.
As an example of changing laod combo's,I experimented with a custom Hawkinsa friend of mine built me.
.58 cal 38" Colrain barrel,1-1/8 tapered profile,lapped and slight taper bore,@.009 from breech to muzzle,slant hook breech.
Original load was .570 ball,spit patch blue pillow ticking,115grs 3f. With this load I was able to hit all 4 Bears on the NMLRA 200yd sillouete match,ONCE!
After numerous shoulder surgeries,non sucsessful,I needed to find a milder load. After what seem's like 1000 years on the range, I was able to hit on an alternate "kinder" load. .562 round ball,spit blue pillow tick,70grs 3f. Still goes through a couple of 2X4's at 50yd's.
All this to say,your accurate load is your hunting load. Once we put aside our "macho man"stuff,we dont need to hurt ourselves to be a sucessfull hunter. A round ball through the heart will drop whatever you shoot at.
