regarding CWD
oomcurt is correct that there is no evidence to suggest humans can contract it from eating meat of animals that have it.
CWD has been known in the western US since the 1960s. I'm betting thousands of muleys, white-tails, elk, and even moose have been eaten that were infected.
HOWEVER, there is abundant evidence, some might even say proof, that a form of a disease related to CWD, called Creutzfeld-Jakob (CJD) or variant Creutzfeld-Jakob disease (vCJD) is contracted by people that eat beef from animals that have bovine spongiform encephalopathy (BSE), also called "mad cow disease".
CWD in deer, mad cow in cattle, CJD and vCJD in humans, and scrapie in sheep are all similar diseases, so it may well be only a matter of time before epidemiologists determine if humans can get 'sick' by eating CWD-infected deer.
To each his own, but if I was hunting in CWD infected areas, or if it ever gets to PA, I'll be having my deer tested before consuming.
You can protect yourself by deboning all meat, removing lymph nodes (there are some that sit between the muscles of the hams), not using a bone saw to cut through meat and bone when processing, and having the deer tested, but this will cost a few bucks (about $40 or $50 in PA).
And it's always sensible to wear latex or rubber gloves when dressing any game. There are lots of crazy diseases and conditions people can get from gutting and handling wild meat. You ABSOLUTELY could contract rabies this way - a little blood in a cut, a squirt of blood or some other fluid in the eye or mouth. And deer can and do carry rabies, not just bats and coons and skunks and foxes. Any mammal can have rabies. Many diseases have a long incubation period. For example, it can take 6-18 months for an animal with CWD to show symptoms!
I knew personally a biologist who died because he didn't take precautions when dressing (actually performing a necropsy) on a mountain lion in Arizone a couple of years ago. Spend 50 cents on a pair of dressing gloves and wash afterwards - it might just save your life or prevent a rash or feeling really sick!