trying to make one caliber long gun do it all, from skwerls to yotes to deer, will always be a compromise of sorts.  hence why most of us have varied calibers and types of long guns.  i had a real nice jack garner .36 flinter that i should not have sold, a very potent skwerl rifle.  for yotes to deer, hard to beat a .50 though the right .45 can mostly work.  for the larger game it'd have to be a .54 and up - i prefer a .62 smooth rifle, which can easily do for most small to large game because it'll throw both shot as well as ball.