I wasn't sure so I had to look it up...
From the Texas State Library and Archives Commission:
Cherokee
The Cherokees were one of the principal Indian nations of the southeastern United States. Wars, epidemics, and food shortages caused many Cherokees to migrate west to Missouri, Arkansas, and Texas in hopes of preserving their traditional way of life. Those who remained behind in the Southeast were eventually removed forcibly to Indian Territory (Oklahoma) in the incident known as the “Trail of Tears.”
Cherokees settled in Texas near the Red River. Pressed further south by American settlement, in 1820 about sixty families under Chief Bowl (Duwali) settled in Rusk County near the Caddos. As Americans settled that area, distrust grew between them and the Cherokees. Hoping to gain a legal title to their land, the Cherokees invested a great deal of energy in cultivating a relationship with Mexico. Hoping to protect this relationship, they remained neutral between Texas and Mexico during the Texas Revolution.
Sam Houston was an adopted member of the Cherokee tribe and a forceful advocate for the people. He negotiated a permanent reservation for the tribe in East Texas, but the treaty was never ratified by the Texas Congress. Under President Lamar, Texas fought a war with the Cherokees in 1839 which resulted in the defeat of the Indians. Most Cherokees were forced into Indian Territory.