If I am using heavy powder charges, I do. I find that 20 ga cushion wads work well in my .62, 14 ga wads in the .69 and 12 ga. in the .72 and of course, 8 ga in the 8 bore.
On my rifles, 150 grains of powder seems to be the point where I start to get burnt patches.
I also find that by pushing a cushion wad down it wipes the bore of fouling and leaves a light coat of lube on the barrel, making it easier to wipe of the crud on the next shot.
Also, in chronograph tests, I have found that having the additional sealing properties of the wad, I get a little better velocity out of a given charge using the wad.
A 28 ga wad will work pretty good in .54 and .58 rifles.
And of course, there is the old weasel clause, YMMV.