I have a Caywood .62 smoothie. I load both shot and PRB. With this gun I've taken a half dozen gobblers and several geese with shot, but have not yet hunted with PRB.
I have used both FFg and FFFg and have settled on 3f for my main charge. I got good results from both, but I like 3f because I can prime with it as well with no perceptible change in ignition speed from using 4f and so I only need to buy one powder.
For shot: For hunting geese and ducks, I load 80gr - 90gr. 3f, one over-powder card, 1 pre-lubed felt wad, then 1 oz Bismuth #4 (measured with a shot measure). I find with the heavy felt wads, they tend to blow through the pattern and create a sort of "doughnut" effect. Fine for shooting flying targets out to 25 yards, but not good for turkeys.
I have done a lot of experimenting for turkey loads, and have used everything up to 100gr. powder / 1 1/2oz. shot, plastic shot cups, paper shot cups, fiber wads, felt wads, etc. My best turkey load patterns are with 80gr. 3f, 4 thin over-powder cards on the charge, 1 1/8oz #6 lead (about 100gr. equiv. in my powder measure) and 1 overshot card to hold it all in. My gun is also a straight cylinder bore, and this gives me 100% certainly to 20 yards, and perhaps a few yards extra. I found a visible difference in eliminating the thick wads/cards on top of the charge, and my patterns have a nice dense core with using only thin cards. Plastic shot cups did provide a minor advantage (maybe a few extra yards) but I chose not to use them as it didn't feel right to be loading plastic into a PC gun. My experiments with paper shot cups were a dismal failure as I got no consistency. I'm sure that is the fault of my technique, but I abandoned the experiments none-the-less.
I have also tried lead #4 and the edge went to #6's for pattern density. With a max. range of say 25 yards, #6's retain more than enough energy to penetrate the head/neck of a gobbler. Although, every gun if different. My T/C New Englander patterns #4's tighter than #6's, so the turkeys I killed with it fell to #4's.
For PRB: I have never hunted with PRB, but my gun shoots very well with anywhere from 60 - 80gr. 3f and a 0.595" roundball in lubed 0.010" patch. Point of impact changes with the variance in powder charge, but grouping is surprisingly similar. This load is not too tight in my smoothie, but shoots well (about 3-4" at 25 yards and 8" at 50). I don't like a PRB combo that needs real force to load, and I don't see the necessity to do so in a smooth bore anyway. I have tried different combos, but always came back to the .595" ball / 0.010" patch. Part of the reason I went with 0.595" balls is because I don't cast my own and they are more economical - they fall right on the price break at TOTW (.595" balls are $10.25 for 50 and .600" are $7.95 for 25). I figure there's no game in my neck of the woods that will notice the 0.005" difference in ball diameter, and it saves me a little more than a dime per shot.