Unless you are planning to enter some sort of juried event, forget the 100% hand sewing. I once won a competition where one of the judges wanted to examine all clothing for total hand sewing. Cooler heads prevailed (thanks, ladies!) and I didn't have to disrobe.
Many times people sew all seams with a machine and then hand finish areas where stitching shows, like collar, cuffs, neck opening, any top stitching. That way it looks "right," but you save yourself HOURS of work where no one will (or should) look.
For your first shirt, you might want to machine sew it all, because you are trying to understand the way a shirt goes together. Do it with cheap fabric at first until you get the lay of the land, then go for more authenticity in both materials and method.